Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies

• Main Authors: Raquel B. M. de Almeida (Author), Deyse B. Barbosa (Author), Mayra R. do Bomfim (Author), Jéssika A. O. Amparo (Author), Bruno S. Andrade (Author), Silvia L. Costa (Author), Joaquín M. Campos (Author), Jorddy N. Cruz (Author), Cleydson B. R. Santos (Author), Franco H. A. Leite (Author), Mariana B. Botura (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The enhancement of cholinergic functions via acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition is considered a valuable therapeutic strategy for the treatment of Alzheimer's disease. This study aimed to evaluate the in vitro effect of ZINC390718, previously filtered using...