Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways

Abstract Background Pirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying a foundation for clinical application. Methods Pulmonary fibrosis mice...

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Main Authors: Qun Lv (Author), Jianjun Wang (Author), Changqing Xu (Author), Xuqing Huang (Author), Zhaoyang Ruan (Author), Yifan Dai (Author)
Format: Book
Published: BMC, 2020-05-01T00:00:00Z.
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