Boosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles

• Main Authors: Miguel Pinto (Author), Carlos Fernandes (Author), Eva Martins (Author), Renata Silva (Author), Sofia Benfeito (Author), Fernando Cagide (Author), Ricardo F. Mendes (Author), Filipe A. Almeida Paz (Author), Jorge Garrido (Author), Fernando Remião (Author), Fernanda Borges (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The current pharmacological treatments for Parkinson’s disease only offer symptomatic relief to the patients and are based on the administration of levodopa and catechol-O-methyltransferase or monoamine oxidase-B inhibitors (IMAO-B). Since the majority of drug candidates fail in pre- and clinical tr...