Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways

• Main Authors: Kaiqiang Sun (Author), Jian Zhu (Author), Yi Deng (Author), Ximing Xu (Author), Fanqi Kong (Author), Xiaofei Sun (Author), Le Huan (Author), Changzhen Ren (Author), Jingchuan Sun (Author), Jiangang Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteolytic bone disease is a condition of imbalanced bone homeostasis, characterized mainly by excessive bone-resorptive activity, which could predispose these populations, such as the old and postmenopausal women, to developing high risk of skeletal fragility and fracture. The nature of bone homeos...