Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis

• Main Authors: Mario Alberto Alarcón-Sánchez (Author), Norma Samanta Romero-Castro (Author), Julieta Sarai Becerra-Ruiz (Author), Selenne Romero-Servin (Author), Artak Heboyan (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The presence of a polymicrobial dysbiotic film in direct and constant contact with periodontal tissues initiates the host immune response. Interleukin 18 (IL-18) triggers up-regulates the production of other proinflammatory cytokines (TNF-α, IL-1β, IL-6), creating a vicious cycle...