Systemic RALA/iNOS Nanoparticles: A Potent Gene Therapy for Metastatic Breast Cancer Coupled as a Biomarker of Treatment

• Main Authors: Cian M. McCrudden (Author), John W. McBride (Author), Joanne McCaffrey (Author), Ahlam A. Ali (Author), Nicholas J. Dunne (Author), Vicky L. Kett (Author), Jonathan A. Coulter (Author), Tracy Robson (Author), Helen O. McCarthy (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to determine the therapeutic benefit of a nanoparticular formulation for the delivery of inducible nitric oxide synthase (iNOS) gene therapy in a model of breast cancer metastasis. Nanoparticles comprising a cationic peptide vector, RALA, and plasmid DNA were formulated and characte...