Review of preclinical data of PF-07304814 and its active metabolite derivatives against SARS-CoV-2 infection

• Main Authors: Wujun Chen (Author), Yingchun Shao (Author), Xiaojin Peng (Author), Bing Liang (Author), Jiazhen Xu (Author), Dongming Xing (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Main protease (Mpro) is a superior target for anti-SARS-COV-2 drugs. PF-07304814 is a phosphate ester prodrug of PF-00835231 that is rapidly metabolized into the active metabolite PF-00835231 by alkaline phosphatase (ALP) and then suppresses SARS-CoV-2 replication by inhibiting Mpro. PF-07304814 inc...