Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2β protein: implications in cross-reactivity.

• Главные авторы: Juan Carlos Pizarro (Автор), Ginette Boulot (Автор), Graham A Bentley (Автор), Karina A Gómez (Автор), Johan Hoebeke (Автор), Mireille Hontebeyrie (Автор), Mariano J Levin (Автор), Cristian R Smulski (Автор)
• Формат: ‌
• Опубликовано: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Patients with Chronic Chagas' Heart Disease possess high levels of antibodies against the carboxyl-terminal end of the ribosomal P2ß protein of Trypanosoma cruzi (TcP2ß). These antibodies, as well as the murine monoclonal antibody (mAb) 17.2, recognize the last 13 amino acids of TcP2ß (called t...