Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2β protein: implications in cross-reactivity.

• Main Authors: Juan Carlos Pizarro (Author), Ginette Boulot (Author), Graham A Bentley (Author), Karina A Gómez (Author), Johan Hoebeke (Author), Mireille Hontebeyrie (Author), Mariano J Levin (Author), Cristian R Smulski (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with Chronic Chagas' Heart Disease possess high levels of antibodies against the carboxyl-terminal end of the ribosomal P2ß protein of Trypanosoma cruzi (TcP2ß). These antibodies, as well as the murine monoclonal antibody (mAb) 17.2, recognize the last 13 amino acids of TcP2ß (called t...