New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke

• Main Authors: Yang Cai (Author), Hongfeng Gu (Author), Lu Li (Author), Xue Liu (Author), Ying Bai (Author), Ling Shen (Author), Bing Han (Author), Yungen Xu (Author), Honghong Yao (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemic stroke is a high-mortality disease that urgently requires new therapeutic strategies. Insufficient cerebral blood supply can induce poly (ADP-ribose) polymerase (PARP) activation and mitochondrial dysfunction, leading to tissue damage and motor dysfunction. We demonstrate that the expressio...