Specific knockout of p85α in brown adipose tissue induces resistance to high-fat diet-induced obesity and its metabolic complications in male mice

• Main Authors: Almudena Gomez-Hernandez (Author), Andrea R. Lopez-Pastor (Author), Carlota Rubio-Longas (Author), Patrik Majewski (Author), Nuria Beneit (Author), Vanesa Viana-Huete (Author), Gema García-Gómez (Author), Silvia Fernandez (Author), Marta Letizia Hribal (Author), Giorgio Sesti (Author), Oscar Escribano (Author), Manuel Benito (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: An increase in mass and/or brown adipose tissue (BAT) functionality leads to an increase in energy expenditure, which may be beneficial for the prevention and treatment of obesity. Moreover, distinct class I PI3K isoforms can participate in metabolic control as well as in systemic dysfunc...