Specific knockout of p85α in brown adipose tissue induces resistance to high-fat diet-induced obesity and its metabolic complications in male mice

• Autori principali: Almudena Gomez-Hernandez (Autore), Andrea R. Lopez-Pastor (Autore), Carlota Rubio-Longas (Autore), Patrik Majewski (Autore), Nuria Beneit (Autore), Vanesa Viana-Huete (Autore), Gema García-Gómez (Autore), Silvia Fernandez (Autore), Marta Letizia Hribal (Autore), Giorgio Sesti (Autore), Oscar Escribano (Autore), Manuel Benito (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2020-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: An increase in mass and/or brown adipose tissue (BAT) functionality leads to an increase in energy expenditure, which may be beneficial for the prevention and treatment of obesity. Moreover, distinct class I PI3K isoforms can participate in metabolic control as well as in systemic dysfunc...