Cysteine proteases in protozoan parasites.

• Main Authors: Jair L Siqueira-Neto (Author), Anjan Debnath (Author), Laura-Isobel McCall (Author), Jean A Bernatchez (Author), Momar Ndao (Author), Sharon L Reed (Author), Philip J Rosenthal (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive chemotherapeutic and vaccine targets. This review h...