Modulation of the Release of a Non-Interacting Low Solubility Drug from Chitosan Pellets Using Different Pellet Size, Composition and Numerical Optimization

• Glavni autori: Ioannis Partheniadis (Autor), Paraskevi Gkogkou (Autor), Nikolaos Kantiranis (Autor), Ioannis Nikolakakis (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2019-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Two size classes of piroxicam (PXC) pellets (mini (380–550 μm) and conventional (700–1200 μm)) were prepared using extrusion/spheronization and medium viscosity chitosan (CHS). Mixture experimental design and numerical optimization were applied to distinguish fo...