Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives

• Main Authors: Xiaole Chen (Author), Min Gao (Author), Rongchao Jian (Author), Weiqian David Hong (Author), Xiaowen Tang (Author), Yuling Li (Author), Denggao Zhao (Author), Kun Zhang (Author), Wenhua Chen (Author), Xi Zheng (Author), Zhaojun Sheng (Author), Panpan Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Embelin is a naturally occurring para-benzoquinone isolated from Embelia ribes (Burm. f.) of the Myrsinaceae family. It was first discovered to have potent inhibitory activity (IC50 = 4.2 μM) against α-glucosidase in this study. Then, four series of novel embelin derivatives were designed, prepared...