Endotrophin neutralization through targeted antibody treatment protects from renal fibrosis in a podocyte ablation model

• Main Authors: Yu A. An (Author), Wei Xiong (Author), Shiuhwei Chen (Author), Dawei Bu (Author), Joseph M. Rutkowski (Author), Joel P. Berger (Author), Christine M. Kusminski (Author), Ningyan Zhang (Author), Zhiqiang An (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Renal fibrosis is a hallmark for chronic kidney disease (CKD), and often leads to end stage renal disease (ESRD). However, limited interventions are available clinically to ameliorate or reverse renal fibrosis. Methods: Herein, we evaluated whether blockade of endotrophin through neutrali...