Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles

Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles

Background: Administering Cinacalcet HCl (CINA) can be challenging because of its low oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor aqueous solubility. However, nanosuspensions are an effective way of enhancing solubility by reducing size. Furthermore, pulmon...

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Main Authors: Katayoon Mireskandari (Author), Mostafa Rostamnezhad (Author), Majid Darabi (Author), Mohammadreza Rouini (Author), Alireza Vatanara (Author)
Format: Book
Published: Tabriz University of Medical Sciences, 2024-04-01T00:00:00Z.
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