Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission

• Main Authors: Takeru Inoue (Author), Koichi Miura (Author), Ruzhe Han (Author), Fumi Seto-Tetsuo (Author), Masaki Arioka (Author), Kazunobu Igawa (Author), Katsuhiko Tomooka (Author), Toshiyuki Sasaguri (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium discoideum that inhibits the proliferation and migration of both D. discoideum and most mammalian cells. Herein, we assessed the effect of DIF-1 on mitochondria, because DIF-3, which is similar to DIF-1, reportedly lo...