Direct detection of RNA modifications and structure using single-molecule nanopore sequencing

• Main Authors: William Stephenson (Author), Roham Razaghi (Author), Steven Busan (Author), Kevin M. Weeks (Author), Winston Timp (Author), Peter Smibert (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition, modifications can be introduced to RNA molecules using chemical probing strategies t...