Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity

• Main Authors: Annalisa Canta (Author), Alessia Chiorazzi (Author), Eleonora Pozzi (Author), Giulia Fumagalli (Author), Laura Monza (Author), Cristina Meregalli (Author), Valentina A. Carozzi (Author), Virginia Rodriguez-Menendez (Author), Norberto Oggioni (Author), Jacques Näsström (Author), Paola Marmiroli (Author), Guido Cavaletti (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin (OHP) is an antineoplastic compound able to induce peripheral neurotoxicity. Oxidative stress has been suggested to be a key factor in the development of OHP-related peripheral neurotoxicity. Mangafodipir, a contrast agent possessing mitochondrial superoxide dismutase (MnSOD)-mimetic act...