A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

Somatic mutations activating MAPK and PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumours based on somatic expression of oncogenes that activate MAPK and PI3K signalling in neural progenitor cells and found that HRASV...

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Main Authors: Marie Mayrhofer (Author), Victor Gourain (Author), Markus Reischl (Author), Pierre Affaticati (Author), Arnim Jenett (Author), Jean-Stephane Joly (Author), Matteo Benelli (Author), Francesca Demichelis (Author), Pietro Luigi Poliani (Author), Dirk Sieger (Author), Marina Mione (Author)
Format: Book
Published: The Company of Biologists, 2017-01-01T00:00:00Z.
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