Preimplantation Genetic Testing Prevented Intergenerational Transmission of X-Linked Alport Syndrome

• Main Authors: Xiaoling Hu (Author), Jiahui Zhang (Author), Yuan Lv (Author), Xijing Chen (Author), Guofang Feng (Author), Liya Wang (Author), Yinghui Ye (Author), Fan Jin (Author), Yimin Zhu (Author)
• Format: Book
• Published: Karger Publishers, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Alport syndrome (AS) is a hereditary renal basement membrane disease that can lead to end-stage renal disease in young adults. It can be diagnosed by genetic analysis, being mostly caused by mutations in COL4A3, COL­4A4, and COL4A5. To date, there is no radical cure for this disease. Obj...