Tp53 Mutation Inhibits Ubiquitination and Degradation of WISP1 via Down-Regulation of Siah1 in Pancreatic Carcinogenesis

• Main Authors: Wei Wu (Author), Xu Liu (Author), Lumin Wei (Author), Tong Li (Author), Yi Zang (Author), Yuting Qian (Author), Tingting Bai (Author), Juanjuan Li (Author), Mingping Xie (Author), Ying Zhu (Author), Qi Wang (Author), Lifu Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wnt1 inducible signaling pathway protein-1 (WISP1) may play an important role in promoting carcinogenesis. However, the biological function and underlying mechanism of WISP1 in pancreatic carcinogenesis still remains enigmatic. In this study, immunochemistry staining showed that protein levels of WI...