Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid

• Main Authors: Ningning Zheng (Author), Yu Gu (Author), Ying Hong (Author), Lili Sheng (Author), Linlin Chen (Author), Feng Zhang (Author), Jie Hou (Author), Weidong Zhang (Author), Zean Zhang (Author), Wei Jia (Author), Houkai Li (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver injury caused by acetaminophen (AP) overdose is a leading public health problem. Although AP-induced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone (NAPQI), a toxic metabolite of AP, resulting in cell damage, emerging evidence indicates that AP-induced liver injury...