PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

• প্রধান লেখক: Chie Emoto (Author), Trevor N. Johnson (Author), Sibylle Neuhoff (Author), David Hahn (Author), Alexander A. Vinks (Author), Tsuyoshi Fukuda (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2018-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) were previously demonstrated in children, whereas chan...