An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing

Abstract Background Multi-sample comparison is commonly used in cancer genomics studies. By using next-generation sequencing (NGS), a mutation's status in a specific sample can be measured by the number of reads supporting mutant or wildtype alleles. When no mutant reads are detected, it could...

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Main Authors: Nicholas Hutson (Author), Fenglin Zhan (Author), James Graham (Author), Mitsuko Murakami (Author), Han Zhang (Author), Sujana Ganaparti (Author), Qiang Hu (Author), Li Yan (Author), Changxing Ma (Author), Song Liu (Author), Jun Xie (Author), Lei Wei (Author)
Format: Book
Published: BMC, 2021-12-01T00:00:00Z.
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