Mechanistic pharmacokinetic-pharmacodynamic modeling and simulations of naloxone auto‐injector 10 mg reversal of opioid‐induced respiratory depression

• Main Authors: Tae Eun Yang (Author), Francesca Del Bene (Author), Silvia Maria Lavezzi (Author), Laura Iavarone (Author), Jianping Zhang (Author), Joseph Kim (Author), Breanne Gjurich (Author), Catherine Kessler (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The purpose of the analysis was to evaluate if 10 mg naloxone, administered intramuscularly, could reverse or prevent opioid‐induced respiratory depression (OIRD), including OIRD associated with the administration of lethal doses of high‐potency opioids. A naloxone population pharmacokineti...