Identification of peptide mimotopes of Trypanosoma brucei gambiense variant surface glycoproteins.

• Main Authors: Liesbeth Carolien Van Nieuwenhove (Author), Stijn Rogé (Author), Fatima Balharbi (Author), Tessa Dieltjens (Author), Thierry Laurent (Author), Yves Guisez (Author), Philippe Büscher (Author), Veerle Lejon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense. These native VSGs are difficult to produce, and contain non-specific epitopes that may...