Combined CCNE1 high‐level amplification and overexpression is associated with unfavourable outcome in tubo‐ovarian high‐grade serous carcinoma

• Main Authors: Angela MY Chan (Author), Emeka Enwere (Author), John B McIntyre (Author), Holly Wilson (Author), Chidera Nwaroh (Author), Nicholas Wiebe (Author), Young Ou (Author), Shuhong Liu (Author), Katharina Wiedemeyer (Author), Peter F Rambau (Author), Xin Grevers (Author), Donald G Morris (Author), Paola Neri (Author), C Blake Gilks (Author), Frank Visser (Author), Nhu Le (Author), Li Luo (Author), Linda S Cook (Author), Martin Köbel (Author)
• Format: Book
• Published: Wiley, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract CCNE1 amplification is a recurrent alteration associated with unfavourable outcome in tubo‐ovarian high‐grade serous carcinoma (HGSC). We aimed to investigate whether immunohistochemistry (IHC) can be used to identify CCNE1 amplification status and to validate whether CCNE1 high‐level ampli...