Semimechanistic Clearance Models of Oncology Biotherapeutics and Impact of Study Design: Cetuximab as a Case Study

• Main Authors: Ana‐Marija Grisic (Author), Akash Khandelwal (Author), Mauro Bertolino (Author), Wilhelm Huisinga (Author), Pascal Girard (Author), Charlotte Kloft (Author)
• Format: Book
• Published: Wiley, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to explore the currently competing and new semimechanistic clearance models for monoclonal antibodies and the impact of clearance model misspecification on exposure metrics under different study designs exemplified for cetuximab. Six clearance models were investigated under four dif...