A detachable coating of cholesterol-anchored PEG improves tumor targeting of cell-penetrating peptide-modified liposomes

• Main Authors: Jie Tang (Author), Li Zhang (Author), Han Fu (Author), Qifang Kuang (Author), Huile Gao (Author), Zhirong Zhang (Author), Qin He (Author)
• Format: Book
• Published: Elsevier, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell-penetrating peptides (CPPs) have been widely used to enhance the membrane translocation of various carriers for many years, but the non-specificity of CPPs seriously limits their utility in vivo. In this study, cholesterol-anchored, reduction-sensitive PEG (first synthesized by our laboratory)...