Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells.

• Main Authors: Lindsay Lundberg (Author), Chelsea Pinkham (Author), Cynthia de la Fuente (Author), Ashwini Brahms (Author), Nazly Shafagati (Author), Kylie M Wagstaff (Author), David A Jans (Author), Sharon Tamir (Author), Kylene Kehn-Hall (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185, KPT-335 (verdinexor), and KPT-350, target the host...