Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules

• Main Authors: Kazuya Kabei (Author), Yu Tateishi (Author), Masakazu Nozaki (Author), Masako Tanaka (Author), Masayuki Shiota (Author), Mayuko Osada-Oka (Author), Shunji Nishide (Author), Junji Uchida (Author), Tatsuya Nakatani (Author), Shuhei Tomita (Author), Katsuyuki Miura (Author)
• Format: Book
• Published: Elsevier, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study is to clarify the role of hypoxia-inducible factor-1 (HIF-1) in the development of renal fibrosis in mouse obstructive nephropathy. We used mice with floxed HIF-1α alleles and tamoxifen-inducible Cre/ERT2 recombinase under ubiquitin C promoter to induce global HIF-1α deletion. F...