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Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators

Abstract Background Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibitor (referred to as UAMC1110) with low nanomolar FA...

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Main Authors: Euy Sung Moon (Author), Filipe Elvas (Author), Gwendolyn Vliegen (Author), Stef De Lombaerde (Author), Christel Vangestel (Author), Sven De Bruycker (Author), An Bracke (Author), Elisabeth Eppard (Author), Lukas Greifenstein (Author), Benedikt Klasen (Author), Vasko Kramer (Author), Steven Staelens (Author), Ingrid De Meester (Author), Pieter Van der Veken (Author), Frank Rösch (Author)
Format: Book
Published: SpringerOpen, 2020-07-01T00:00:00Z.
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