Two-Step Optimization to Develop a Transdermal Film Loaded With Dapoxetine Nanoparticles: A Promising Technique to Improve Drug Skin Permeation

• Asıl Yazarlar: Tarek A. Ahmed (Yazar), Asmaa M. S. Alay (Yazar), Solomon Z. Okbazghi (Yazar), Nabil A. Alhakamy (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: SAGE Publishing, 2020-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Dapoxetine (DPX) is an orally administered drug for the treatment of premature ejaculation (PE). One of the challenges of administering DPX orally as a tablet is its poor bioavailability (ie, 42%) due to extensive first-pass metabolism. Thus, it is vital to develop a new formulation and mode of deli...