Two-Step Optimization to Develop a Transdermal Film Loaded With Dapoxetine Nanoparticles: A Promising Technique to Improve Drug Skin Permeation

• 主要な著者: Tarek A. Ahmed (著者), Asmaa M. S. Alay (著者), Solomon Z. Okbazghi (著者), Nabil A. Alhakamy (著者)
• フォーマット: 図書
• 出版事項: SAGE Publishing, 2020-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Dapoxetine (DPX) is an orally administered drug for the treatment of premature ejaculation (PE). One of the challenges of administering DPX orally as a tablet is its poor bioavailability (ie, 42%) due to extensive first-pass metabolism. Thus, it is vital to develop a new formulation and mode of deli...