An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation

• Main Authors: Yu Chen (Author), Jialun Wang (Author), Ying Huang (Author), Jianzhuang Wu (Author), Yue Wang (Author), Aotian Chen (Author), Qiyuan Guo (Author), Yixuan Zhang (Author), Shu Zhang (Author), Lei Wang (Author), Xiaoping Zou (Author), Xihan Li (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Hypoxia is one of the important reasons for the poor therapeutic efficacy of current pancreatic cancer treatment, and the dense stroma of pancreatic cancer restricts the diffusion of oxygen within the tumor. Methods: A responsive oxygen-self-supplying adv-miRT-CAT-KR (adv-MCK) cascade...