The EDA-deficient mouse has Zymbal's gland hypoplasia and acute otitis externa

• Main Authors: Jorge del-Pozo (Author), Denis J. Headon (Author), James D. Glover (Author), Ali Azar (Author), Sonia Schuepbach-Mallepell (Author), Mahmood F. Bhutta (Author), Jon Riddell (Author), Scott Maxwell (Author), Elspeth Milne (Author), Pascal Schneider (Author), Michael Cheeseman (Author)
• Format: Book
• Published: The Company of Biologists, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In mice, rats, dogs and humans, the growth and function of sebaceous glands and eyelid Meibomian glands depend on the ectodysplasin signalling pathway. Mutation of genes encoding the ligand EDA, its transmembrane receptor EDAR and the intracellular signal transducer EDARADD leads to hypohidrotic ect...