Discovery and Characterization of the Key Constituents in Ginkgo biloba Leaf Extract With Potent Inhibitory Effects on Human UDP-Glucuronosyltransferase 1A1

• Main Authors: Hui-Lin Pang (Author), Guang-Hao Zhu (Author), Qi-Hang Zhou (Author), Chun-Zhi Ai (Author), Ya-Di Zhu (Author), Ping Wang (Author), Tong-Yi Dou (Author), Yang-Liu Xia (Author), Hong Ma (Author), Guang-Bo Ge (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human UDP-glucuronosyltransferase 1A1 (hUGT1A1) is one of the most essential phase II enzymes in humans. Dysfunction or strong inhibition of hUGT1A1 may result in hyperbilirubinaemia and clinically relevant drug/herb-drug interactions (DDIs/HDIs). Recently, a high-throughput fluorescence-based assay...