Synthesis and Characterization of Chemically and Green-Synthesized Silver Oxide Particles for Evaluation of Antiviral and Anticancer Activity
Silver oxide (Ag<sub>2</sub>O) particles are wonderful candidates due to their unique properties, and their use in a wide range of research, industrial and biomedical applications is rapidly increasing. This makes it fundamental to develop simple, environmentally friendly methods with po...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
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MDPI AG,
2024-07-01T00:00:00Z.
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| Summary: | Silver oxide (Ag<sub>2</sub>O) particles are wonderful candidates due to their unique properties, and their use in a wide range of research, industrial and biomedical applications is rapidly increasing. This makes it fundamental to develop simple, environmentally friendly methods with possible scaling. Herein, sodium borohydride and <i>Datura innoxia</i> leaf extract were applied as chemical and biological stabilizing and reducing agents to develop Ag<sub>2</sub>O particles. The primary aim was to evaluate the anticancer and antiviral activity of Ag<sub>2</sub>O particles prepared via two methods. XRD, UV-visible and SEM analyses were used to examine the crystallite structure, optical properties and morphology, respectively. The resulting green-synthesized Ag<sub>2</sub>O particles exhibited small size, spherically agglomerated shape, and high anticancer and antiviral activities compared to chemically synthesized Ag<sub>2</sub>O particles. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium-bromide) assay of green-synthesized Ag<sub>2</sub>O particles showed high anticancer activity against MCF-7 cells with IC<sub>50</sub> = 17.908 µg/mL compared to chemically synthesized Ag<sub>2</sub>O particles with IC<sub>50</sub> = 23.856 µg/mL. The antiviral activity of green-synthesized Ag<sub>2</sub>O particles and chemically synthesized Ag<sub>2</sub>O particles was also evaluated by a plaque-forming assay, and green-synthesized Ag<sub>2</sub>O particles showed higher antiviral ability with IC<sub>50</sub> = 0.618 µg/mL as compared to chemically synthesized Ag<sub>2</sub>O particles with IC<sub>50</sub> = 6.129 µg/mL. We propose the use of green-synthesized Ag<sub>2</sub>O particles in cancer treatment and drug delivery. |
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| Item Description: | 10.3390/ph17070908 1424-8247 |