Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice

Objective: Hyperinsulinemia is commonly associated with obesity. Mice deficient in the adipose-derived hormone leptin (Lepob/ob) develop hyperinsulinemia prior to onset of obesity and glucose intolerance. Whether the excess of circulating insulin is a major contributor to obesity and impaired glucos...

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Main Authors: Anna M. D'souza (Author), James D. Johnson (Author), Susanne M. Clee (Author), Timothy J. Kieffer (Author)
Format: Book
Published: Elsevier, 2016-11-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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