Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice
Objective: Hyperinsulinemia is commonly associated with obesity. Mice deficient in the adipose-derived hormone leptin (Lepob/ob) develop hyperinsulinemia prior to onset of obesity and glucose intolerance. Whether the excess of circulating insulin is a major contributor to obesity and impaired glucos...
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Main Authors: | , , , |
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Format: | Book |
Published: |
Elsevier,
2016-11-01T00:00:00Z.
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Call Number: |
A1234.567 |
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Copy 1 | Available |