Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh.

• Main Authors: Amena Aktar (Author), M Arifur Rahman (Author), Sadia Afrin (Author), Aklima Akter (Author), Taher Uddin (Author), Tahirah Yasmin (Author), Md Israk Nur Sami (Author), Pinki Dash (Author), Sultana Rownok Jahan (Author), Fahima Chowdhury (Author), Ashraful I Khan (Author), Regina C LaRocque (Author), Richelle C Charles (Author), Taufiqur Rahman Bhuiyan (Author), Anjali Mandlik (Author), Meagan Kelly (Author), Pavol Kováč (Author), Peng Xu (Author), Stephen B Calderwood (Author), Jason B Harris (Author), Firdausi Qadri (Author), Edward T Ryan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The mediators of protection against cholera, a severe dehydrating illness of humans caused by Vibrio cholerae, are unknown. We have previously shown that plasma IgA as well as memory B IgG cells targeting lipopolysaccharide (LPS) of Vibrio cholerae O1 correlate with protection against V....