IL-1β-Induced CXCL10 Expression in THP-1 Monocytic Cells Involves the JNK/c-Jun and NF-κB-Mediated Signaling

• Main Authors: Shihab Kochumon (Author), Amnah Al-Sayyar (Author), Texy Jacob (Author), Hossein Arefanian (Author), Fatemah Bahman (Author), Nourah Almansour (Author), Fawaz Alzaid (Author), Fahd Al-Mulla (Author), Sardar Sindhu (Author), Rasheed Ahmad (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CXCL10 (IP-10) plays a key role in leukocyte homing to the inflamed tissues and its increased levels are associated with the pathophysiology of various inflammatory diseases including obesity and type 2 diabetes. IL-1β is a key proinflammatory cytokine that is found upregulated in meta-inflammatory...