Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human geneti...

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Main Authors: Melissa N. Hinman (Author), Jared I. Richardson (Author), Rose A. Sockol (Author), Eliza D. Aronson (Author), Sarah J. Stednitz (Author), Katrina N. Murray (Author), J. Andrew Berglund (Author), Karen Guillemin (Author)
Format: Book
Published: The Company of Biologists, 2021-06-01T00:00:00Z.
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