Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy

• Asıl Yazarlar: Melissa N. Hinman (Yazar), Jared I. Richardson (Yazar), Rose A. Sockol (Yazar), Eliza D. Aronson (Yazar), Sarah J. Stednitz (Yazar), Katrina N. Murray (Yazar), J. Andrew Berglund (Yazar), Karen Guillemin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2021-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human geneti...