Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody

• Main Authors: Simon A. Hinke (Author), Anne M. Cieniewicz (Author), Thomas Kirchner (Author), Katharine D'Aquino (Author), Rupesh Nanjunda (Author), Jason Aligo (Author), Robert Perkinson (Author), Philip Cooper (Author), Ken Boayke (Author), Mark L. Chiu (Author), Steve Jarantow (Author), Eilyn R. Lacy (Author), Yin Liang (Author), Dana L. Johnson (Author), Jean M. Whaley (Author), Russell B. Lingham (Author), Anthony J. Kihm (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin resistance is a key feature of Type 2 Diabetes (T2D), and improving insulin sensitivity is important for disease management. Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal...