Antagonizing αvβ3 Integrin Improves Ischemia-Mediated Vascular Normalization and Blood Perfusion by Altering Macrophages

• Main Authors: Yongjie Li (Author), Qian Gao (Author), Xin Shu (Author), Lamei Xiao (Author), Yan Yang (Author), Ningbo Pang (Author), Yulin Luo (Author), Jing He (Author), Liping Zhang (Author), Jianbo Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: αVβ3 integrin has been implicated in the physiological processes and pathophysiology of important angiogenesis-related disorders; however, the preclinical and clinical data on integrin αVβ3 antagonists have not demonstrated improved outcomes. Our goal was to test the hypothesis that inhi...