Weaning Mice and Adult Mice Exhibit Differential Carbon Tetrachloride-Induced Acute Hepatotoxicity

• Main Authors: Tae Bin Jeong (Author), Doyoung Kwon (Author), Seung Won Son (Author), Sou Hyun Kim (Author), Yun-Hee Lee (Author), Min-Soo Seo (Author), Kil Soo Kim (Author), Young-Suk Jung (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age is a risk factor for drug-induced liver injury (DILI). However, there is a limited understanding of pediatric DILI. Here, 2-week-old weaning and 8-week-old adult male ICR mice were intraperitoneally injected with CCl₄ (0.1 mmol/kg equal to 15.4 mg/kg) to comparatively eval...