Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: The Extracellular Calcium Receptor and an Innovative Medical Approach to Control Secondary Hyperparathyroidism by Calcimimetics

• Main Authors: Nobuo Nagano (Author), Edward F. Nemeth (Author)
• Formato: Libro
• Publicado: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Circulating levels of calcium ion (Ca2+) are maintained within a narrow physiological range mainly by the action of parathyroid hormone (PTH) secreted from parathyroid cells. Parathyroid cells can sense small fluctuations in plasma Ca2+ levels by virtue of a cell surface Ca2+ receptor (CaR) that bel...