Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis

• Ngā kaituhi matua: Hongtao Yu (Author), Peter Greasley (Author), Hiddo Lambers-Heerspink (Author), David W. Boulton (Author), Bengt Hamrén (Author), K. Melissa Hallow (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Endothelin-1 (ET-1) is a potent vasoconstrictor with strong anti-natriuretic and anti-diuretic effects. While many experimental studies have elucidated the mechanisms of ET-1 through its two receptors, ETA and ETB, the complexity of responses and sometimes conflicting data make it challenging to und...