Imidazopyridine-fused [1,3]diazepinones: modulations of positions 2 to 4 and their impacts on the anti-melanoma activity

• Main Authors: Paul Le Baccon-Sollier (Author), Yohan Malki (Author), Morgane Maye (Author), Lamiaa M. A. Ali (Author), Laure Lichon (Author), Pierre Cuq (Author), Laure-Anaïs Vincent (Author), Nicolas Masurier (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 19 novel pyrido-imidazodiazepinones, with modulations of positions 2, 3 and 4 of the diazepine ring were synthesised and screened for their in vitro cytotoxic activities against two melanoma cell lines (A375 and MDA-MB-435) and for their potential toxicity against NIH-3T3 non-cancerous c...