Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

• Main Authors: Xiao Liu (Author), Zhengcong Cao (Author), Nannan Liu (Author), Guangxun Gao (Author), Mingrui Du (Author), Yingwen Wang (Author), Boyang Cheng (Author), Maorong Zhu (Author), Bo Jia (Author), Luxiang Pan (Author), Wangqian Zhang (Author), Yuran Jiang (Author), Wei He (Author), Linlin Xu (Author), Wei Zhang (Author), Qunxing An (Author), Qingdong Guo (Author), Jintao Gu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most malignant tumor of the central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role in the treatment of GBM. However, major impediments to effective treatment are postoperative tumor recurrence and acquired resistance to ch...