Preclinical development of BCG.HIVA2auxo.int, harboring an integrative expression vector, for a HIV-TB Pediatric vaccine. Enhancement of stability and specific HIV-1 T-cell immunity

• Main Authors: Aakash Mahant (Author), Narcís Saubi (Author), Yoshiki Eto (Author), Núria Guitart (Author), Josep Ma Gatell (Author), Tomáš Hanke (Author), Joan Joseph (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the critical issues that should be addressed in the development of a BCG-based HIV vaccine is genetic plasmid stability. Therefore, to address this issue we have considered using integrative vectors and the auxotrophic mutant of BCG complemented with a plasmid carrying a wild-type complementi...